| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1395535 | European Journal of Medicinal Chemistry | 2015 | 6 Pages |
Abstract
•Novel FMDP derivatives were synthesized.•Antimicrobial activity of FMDP amides was evaluated.•Primary amide of FMDP was the most active compound.•Docking studies of the FMDP derivatives have been performed.
Novel FMDP amides 4–6 have been synthesized and tested against Candida strains. The anticandidal activity has been confined only to Candida albicans. Anticandidal activity of the tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free extract from C. albicans.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dorota Pawlak, Magdalena Stolarska, Marek Wojciechowski, Ryszard Andruszkiewicz,