Quinone reductase induction activity of methoxylated analogues of resveratrol

Agents that induce the activity of phase II enzymes play an important role in intervening with the carcinogenic process at the initiation stage. Resveratrol is well known for its chemopreventive activity against major stages of carcinogenesis. In this study, several methoxylated analogues of resveratrol were synthesized and evaluated for their ability to induce the activity of the phase II enzyme quinone reductase (QR). Methoxy groups serve to increase lipophilicity and improve metabolic stability. Compared to resveratrol, analogues with ortho-methoxy substituents were found to be more potent inducers of QR and to exert their activity in a qualitatively different manner. The greater induction activities associated with these stilbenoids serve as a useful starting point for the design of improved chemopreventive agents.

Graphical abstractAnalogues of resveratrol with ortho-methoxy groups were found to be more potent inducers of quinone reductase and to exert activity in a qualitatively different manner from resveratrol.Figure optionsDownload full-size imageDownload as PowerPoint slide