Rapid synthesis of sulfone derivatives as potential anti-infectious agents

An original one-pot microwave reaction was developed for the synthesis of sulfone derivatives as new potent antimicrobial agents. This eco-friendly methodology conducted in 30 min led to desired products with good yields. The sulfones (4a and 4b) were obtained via the reaction of 3a with the corresponding halo-derivatives in the presence of sodium hydride.All compounds were tested for their antibacterial and antifungal activities against four bacterial strains (two gram positive, and two gram negative ones) and two yeasts. The disk diffusion method has shown an interesting antibacterial activity for seven compounds (3b–g and 4b) against Staphylococcus aureus. Among these seven compounds, five derivatives (3b–e and 3g) showed activity against Candida tropicalis.

Graphical abstractAn original one-pot microwave reaction was developed to obtain sulfone derivatives as new potent antimicrobial agents. Two other products were obtained via a reaction with halo-derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slide