Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals

The synthesis and biological evaluation of ethyl 5-amino-4-(3-pyridyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-carboxylates (9–11) is described. We have found that these compounds inhibit AChE with a mild potency, mitigates the [Ca2+]c triggered by high K+, and cause neuroprotection against Ca2+ overloading and free radical-induced neuronal death.

Graphical abstractThe synthesis and biological evaluation of ethyl 5-amino-4-(3-pyridyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-carboxylates (9–11) is described.Figure optionsDownload full-size imageDownload as PowerPoint slide