Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1395780 | European Journal of Medicinal Chemistry | 2006 | 8 Pages |
Abstract
New 4-amino-6,7-diphenylbicyclo[2.2.2]octane derivatives, esters of bicyclo[2.2.2]octan-2-ols and O-methyl oximes of bicyclo[2.2.2]octan-2-ones were synthesised. Their activities against Trypanosoma brucei rhodesiense (STIB 900) and their activity against the K1 strain of Plasmodium falciparum (resistant to chloroquine and pyrimethamine) were determined by use of microplate assays. The cytotoxicity was assessed using L6 cells. The antiprotozoal activities of the new compounds are compared with those of former prepared derivatives and drugs in use. Structure–activity relationships are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
W. Seebacher, C. Schlapper, R. Brun, M. Kaiser, R. Saf, R. Weis,