Article ID Journal Published Year Pages File Type
1395784 European Journal of Medicinal Chemistry 2006 6 Pages PDF
Abstract

Attempts to cleave the C-ring in the bioactive limonoids characteristic of the species Azadirachta indica A. Juss using BF3·OEt2 and (C4H9)4NBr resulted in novel isomeric C-seco limonoids. Structure related cytotoxic properties of the isomers and the native compounds have been studied using brine shrimp lethality bioassay (BSLB) method and molecular descriptors viz., theoretical and chromatographic hydrophobicity constants, oxidation state and molecular modelling studies. The O–O diad distances reveal the significance of the orientation of the furan ring in enhancing the cytotoxicity of the molecule.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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