| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1395794 | European Journal of Medicinal Chemistry | 2014 | 12 Pages |
•Novel pH-sensitive copolymers based on (PCL/PEG) were synthesized.•These copolymers were modified with folic acid and/or acryloyl chloride.•Mixed micelles were formed by co-assembling of folated and acrylated-copolymers.•Interfacial crosslinking of acrylated groups produce armored mixed nanogels.•Drug release and degradation profiles of armored mixed nanogels were investigated.
Novel pH-sensitive, biodegradable and biocompatible copolymers based on polycaprolactone–poly(ethylene glycol) (PCL/PEG) were synthesized and further modified with folic acid and/or acryloyl chloride. The mixed polymeric micelles were formed by self-assembling of folated-copolymer and non-folated-copolymer with different compositions via nanoprecipitation method. The solubilization of quercetin as anti-cancer drug by the mixed micelle with the optimized composition (folated/non-folated 20/80) was more efficient than those made of each one alone. Nanogels with different crosslinking density were produced in the presence of ethylene glycol dimethacrylate (EGDMA) as the crosslinker via a photochemical method. Interfacial crosslinking of acrylated groups were utilized to produce a core–shell spherical nanoparticle to evaluate their in-vitro drug release and degradation rate.
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