Efficient one-pot preparation of novel fused chromeno[2,3-d]pyrimidine and pyrano[2,3-d]pyrimidine derivatives

Some novel chromeno[2,3-d]pyrimidinone, pyrano[2,3-d]pyrimidine, dihydropyrimidine, pyridopyranopyrimidine and pyrimidopyranopyrimidine have been synthesized. The structures of target compounds were confirmed by elemental analyses and spectral data. The antimicrobial activity of all the target synthesized compounds were tested against various microorganismst such as Pseudomonas aeruginosa; Staphylococcus aureus (Bacteria), Aspergillus flavus (Fungus) and Candida albicans (Yeast fungus) by the disc diffusion method. In general, the novel synthesized compounds showed a good antimicrobial activity against the previously mentioned microorganisms.

Graphical abstractSynthesis and Preliminary Antimicrobial Activity of Some New Pyrano[2,3-d]pyrimidine Derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesized some novel pyrimidine derivatives. The structures of which were confirmed by elemental analyses and spectral data. ► The antimicrobial activity of all the target synthesized compounds was tested. ► We can conclude that the entire tested compounds are more active toward bacteria than fungi.