Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives

Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a–d and 15a–h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.

Graphical abstractHydrazinyl thiazolyl coumarin derivatives have been synthesized and screened for in vitro antimicrobial activities against different microbes including Mycobacterium tuberculosis.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We synthesis new biologically active compounds with various pharmacophores. ► Structural confirmation of the synthesized compounds was done by various spectroscopic techniques. ► All compounds exhibited notable antimicrobial activities against different bacteria including Mycobacterium tuberculosis.