Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro

Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3–9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p-FAK, FAK, p-Akt and Akt through β1 integrin-mediated antimetastatic pathway.

Graphical abstractWe report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3–9), which are demonstrated to have therapeutic potential against tumor metastasis through β1 integrin-mediated antimetastatic pathway.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3–9). ► 1 and 2 showed therapeutic potential against tumor cell migration at the level of nanomolar ranges. ► Compound 9 displays antimetastatic potency involving perhaps the inactivation of b1-integrin-mediated signaling pathway.