Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents

A series of novel s-triazine analogs were synthesized and characterized by IR, 1H NMR, 13C NMR, 19F NMR spectroscopy and elemental analysis. Preliminary screening of target compounds against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexneria), four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus clavatus, Candida albicans) and Mycobacterium tuberculosis H37Rv indicated that 5d, 5h, 5n, 5p, 5q, 5r, 5s, 5t and 5u were the most active compounds among twenty one studied. Thus, they were further subjected to in vitro biological evaluation against human prostate cancer cell line (DU-145) and the results indicate that two compounds 5n and 5s were markedly active.

Graphical abstractTwenty one new s-triazine derivatives have been synthesized and evaluated for their efficacy as antimicrobial, antimycobacterial and anticancer agents. The results indicated that some derivatives were potentially active.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A series of novel piperazino(piperidino)-s-triazines have been synthesized. ► Compounds were screened for their in vitro antimicrobial, antimycobacterial and anticancer activities. ► New compounds are characterized adequately by FT-IR, 1H NMR, 13C NMR, 19F NMR spectroscopy and CHN analysis. ► New compounds indicated broad spectrum of potential bioactivities.