One-pot synthesis of pyrazoline derivatised carbazoles as antitubercular, anticancer agents, their DNA cleavage and antioxidant activities

Novel tricyclic carbazoles 4a–k were synthesized in one-pot employing sydnone derivatives 3a–k as masked hydrazines by the ring transformation in presence of conc. HCl and cyclohexanone. The title compounds were screened for anti-tubercular, anti cancer, DNA cleavage, antioxidant activity. MIC, GI50, LC50, TGI were evaluated. The title compounds have exhibited significant antitubercular, DNA cleavage and antioxidant activities and partial anticancer activity.

Graphical abstractNovel carbazoles 4a–k were prepared in one step by the ring transformation of sydnone derivative 3a–k and were screened for anti-tubercular, anti cancer, DNA cleavage, antioxidant activity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► This research article emphasizes the finding of novel pyrazoline derivatised carbazoles. ► The novel compounds are subjected to the screening for their anticancer, antitubercular activities. ► Osiris Property explorer was used to check the toxicity factors and drug score for drug likeliness. ► The potency of the compounds for anticancer, antitubercular, DNA cleavage as well as antioxidant activities are explored.