Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1396251 | European Journal of Medicinal Chemistry | 2010 | 7 Pages |
Abstract
Simple synthetic strategies for the hitherto unreported [1,2,4]triazolo[4,3-a]pyrido[4,3-d]pyrimidines 8 and [1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-b][1,6]naphthyridine-5-one 15 are described based on reaction of thione 3 and 12 with hydrazonoyl chloride 1a–h, respectively. The structures of products 8 and 15 were confirmed by spectroscopic and X-ray crystallographic analyses. Also, the mechanism of such reactions was discussed. In addition, reaction of compound 12 with bromoacetic acid and hydrazine hydrate was investigated. Compounds were screened against 5α-reductase and showed activities with good LD50 and LD90 for all compounds.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Naglaa A. Abdel Hafez, Thoraya A. Farghaly, Mohamed A. Al-Omar, Mohamed M. Abdalla,