Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure–activity relationships (SARs) as antibacterial agent

Multi-component reaction (MCR) involves coupling of p-bromophenol with 2-Benzothiazolethiol, malononitrile and substituted aldehydes in aqueous K2CO3 as green base to synthesize 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes. This multi-component reaction thus offers a higher yield and versatility in the preparation of densely functionalized oxygen heterocycles. The newly synthesized compounds were screened for their antibacterial activities against positive and gram negative pathogenic strains to bacteria. SAR analysis was performed to explore comprehensive structure–activity relationships and a statistically reliable model to explain their antibacterial activities.

Graphical abstractNovel synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes via One-pot multi-component reaction. Screening and SAR analysis for their antibacterial activities against different microorganisms was done.Figure optionsDownload full-size imageDownload as PowerPoint slide