Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents

A series of novel clubbed Isopropylthiazole derivatives triazolothiadiazines 2a–g, dihydro triazolothiadiazoles 3a–g, thioxotriazoles 4a–d, triazolothiadiazole 5, arylideneamino triazolethiones 7a–h and oxadiazolethiones 11a–b were synthesized and characterized by IR, 1H NMR, 13C NMR, elemental and mass spectral analysis. These compounds were evaluated for their preliminary in vitro antibacterial, antifungal and antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth dilution assay method.All the compounds exhibited moderate to significant antibacterial and antifungal activities. Results of the antitubercular screening against M. tuberculosis H37Rv showed compounds 7c and 7d exhibited good antitubercular activity (MIC 4 and 8 μg/mL) respectively, when compared with first line drug such as isoniazid (0.25 μg/mL).

Graphical abstractIn the present study a series of novel clubbed Isopropylthiazole derivatives triazolothiadiazines dihydro triazolothiadiazoles, thioxotriazoles, triazolothiadiazole, arylideneamino triazolethiones and oxadiazolethiones was synthesized and evaluated for their preliminary cytotoxicity, antimicrobial and antitubercular activity.Figure optionsDownload full-size imageDownload as PowerPoint slide