| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396291 | European Journal of Medicinal Chemistry | 2010 | 5 Pages |
Abstract
A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields is presented. Three compounds were found to be moderate active against Mycobacterium tuberculosis. Correlation of structure–biological activity has been done.
Graphical abstractSynthesis, structure and in vitro antituberculosis activity of some new pyridazine derivatives are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dorina Mantu, Mihaela Cătălina Luca, Costel Moldoveanu, Gheorghita Zbancioc, Ionel I. Mangalagiu,