Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing α-aminopyrazines with α-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity.

Graphical abstractDesign, synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives, by systematically varying substitutions, to establish SAR for cytotoxic activity against cancer cell lines, MDA-MB-231, MCF-7, SK-N-SH and Hep G2, reported.Figure optionsDownload full-size imageDownload as PowerPoint slide