| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396331 | European Journal of Medicinal Chemistry | 2010 | 5 Pages |
Abstract
Various substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model. Most of the synthesized compounds showed excellent potency in eight different human tumor cell lines as expected. In order to find the exact cytotoxic mechanism of these 3-aryl-1-isoquinolinamines, we analyzed the cell cycle dynamics by flow cytometry and found that 3-aryl-1-isoquinolinamine 6k-treated HeLa cells were arrested in G2/M phase, which is related to apoptosis.
Graphical abstractVarious substituted 3-aryl-1-isoquinolinamines were designed and synthesized based on the previously constructed CoMFA model.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le, Daulat Bikram Khadka, Suk Hee Cho, Kyung-Tae Lee, Eung-Seok Lee, Young Bok Lee, Chang-Ho Ahn, Won-Jea Cho,