Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1396397 | European Journal of Medicinal Chemistry | 2010 | 6 Pages |
Abstract
A new series of 6,6a,7,8-tetrahydro-5H-naphtho[1,2-e]pyrimido[4,5-b][1,4]diazepines 4a-f and 5a-f were efficiently synthesized in good yields from the reaction of E-2-arylidene-1-tetralones 1 and the respective tri- or tetraaminopyrimidines 2 or 3 under microwave irradiation using DMF as solvent and catalytic amounts of BF3·OEt2. Six of the obtained compounds were selected and tested by the National Cancer Institute (NCI-USA) against 60 different tumor cell lines. In particular, compounds 5a, 5c and 5e presented remarkable anti-tumor activity against melanoma cancer in SK-MEL-5 cell line.
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Related Topics
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Authors
Braulio Insuasty, Angélica García, Jairo Quiroga, Rodrigo Abonia, Manuel Nogueras, Justo Cobo,