Diorganotin(IV) derivatives of ONO tridentate Schiff base: Synthesis, crystal structure, in vitro antimicrobial, anti-leishmanial and DNA binding studies

Six new diorganotin(IV) derivatives of N′-(2-hydroxybenzylidene)formohydrazide (H2L) with general formula R2SnL, where R = Ph (1), Me (2), Bu (3), Oct (4), t-Bu (5), Et (6), and L = [OC6H4CHNNCHO] have been synthesized and characterized by different analytical techniques. Crystal structure of Me2SnL (2) authenticated distorted square-pyramidal geometry around the Sn atom. The CV and UV–Vis spectroscopic data indicated intercalation of complexes into DNA with binding affinity varying in the sequence: 3 (1.69 × 104 M−1) > 1 (1.10 × 104 M−1) > 2 (9.61 × 103 M−1). Some of these compounds were found to be good antibacterial, antifungal and leishmanicidal agents.

Graphical abstractSix new diorganotin(IV) derivatives of N′-(2-hydroxybenzylidene)formohydrazide (H2L) have been synthesised and characterized. These compounds have good DNA binding ability.Figure optionsDownload full-size imageDownload as PowerPoint slide