Article ID Journal Published Year Pages File Type
1396409 European Journal of Medicinal Chemistry 2010 5 Pages PDF
Abstract

As benzothiazole has proven to be good antimicrobial agent, a novel series of Schiff bases of benzothiazole derivatives were synthesized. Thus condensation of 5-[2-(1,3-benzothiazol-2-yl-amino) ethyl]-4-amino-3-mercapto-(4H)-1,2,4-triazole 5 with appropriate aromatic aldehydes afforded 5-[2-(1,3-benzothiazol-2-yl-amino)ethyl]-4-(arylideneamino)-3-mercapto-(4H)-1,2,4-triazoles 6a–g. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data. All the synthesized compounds were screened for their antimicrobial activity.

Graphical abstractA novel series of 5-[2-(1,3-benzothiazol-2-yl-amino) ethyl]-4-(arylideneamino)-3-mercapto-(4H)-1,2,4-triazoles 6a–g were synthesized and evaluated for their antimicrobial activity to identify potential compounds.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
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