Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1396422 | European Journal of Medicinal Chemistry | 2010 | 9 Pages |
Abstract
Ten 1,4-disubstituted 1,2,3-triazoles 2a–2j were prepared and tested for their ability to increase oleic acid oxidation in human myotubes using a high-throughput multiwell assay. Compounds 2e (2-{4-[(1-(3-fluoro-4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methylthio]-2-methylphenoxy}acetic acid) and 2i (2-{4-[(1-(3-chloro-4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)methylthio]-2-methylphenoxy}acetic acid) exhibited potent agonist activities. Compounds 2e and 2i also exhibited powerful agonist effects for both PPARα and PPARδ in a luciferase-based assay. Consequently, these triazoles can be categorized as dual PPAR agonists.
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Related Topics
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Authors
Calin C. Ciocoiu, Nataša Nikolić, Huyen Hoa Nguyen, G. Hege Thoresen, Arne J. Aasen, Trond Vidar Hansen,