Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity

A rapid preparation of compounds (1–24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50 mg/kg p.o. The compound 1-(2′,4′-Chloroacridine-9′-yl)-3-(5′-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti-inflammatory and analgesic activities at the three graded dose of 25, 50 and 100 mg/kg p.o.

Graphical abstractIn the present study, we have synthesized some new substituted acridinyl pyrazoline. The compound (24) has shown most potent anti-inflammatory activity. Figure optionsDownload full-size imageDownload as PowerPoint slide