| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396532 | European Journal of Medicinal Chemistry | 2010 | 6 Pages |
Abstract
Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4′-Dihydroxy-2-methoxystilbene was the most potent (4.6× more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Henrik C. Hansen, Fabrizio S. Chiacchia, Reena Patel, Norman C.W. Wong, Vladimir Khlebnikov, Renata Jankowska, Kalpesh Patel, M. Madhava Reddy,