In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives

A series of 2-methylaminobenzimidazole derivatives (1–11) were synthesized by the reaction of 2-(chloromethyl)-1H-benzimidazole derivatives with primary aromatic amines. All these compounds were characterized by IR, 1H NMR, 13C NMR, GC-MS and elemental analysis. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats. Compounds (7) and (2) showed a potent analgesic (89% at 100 mg/kg b.w) and anti-inflammatory (100% at 100 mg/kg b.w) activities compared with standard drug Nimesulide (100% at 50 mg/kg b.w) respectively. The other compounds showed good analgesic and anti-inflammatory activities.

Graphical abstractSynthesis of 2-methylaminobenzimidazoles derivatives from 2-(chloromethyl)-1H-benzimidazole.Compounds (7) and (2) shows potent analgesic (89%) and anti-inflammatory (100%) activities compared with standard drug Nimesulide.Figure optionsDownload full-size imageDownload as PowerPoint slide