| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396539 | European Journal of Medicinal Chemistry | 2010 | 5 Pages |
Abstract
As part of an ongoing project to develop highly potent anti-tuberculosis therapeutics, six SQ109 derivatives were synthesized and screened in vitro for their anti-tuberculosis activity against the ATCC strain H37Rv and the extensively drug-resistant clinical strain XDR 173. Compound 16 with an extended alkene chain was the most active against both strains of Mycobacterium tuberculosis within a MIC range of 0.5–0.25 μM. Compound 12 and SQ109 were potent within a MIC range of 1–0.5 μM, whilst compound 18 displayed an activity within the MIC range of 0.5–2 μM against both Mycobacterium tuberculosis strains.
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Related Topics
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Organic Chemistry
Authors
Oluseye K. Onajole, Patrick Govender, Paul D. van Helden, Hendrik G. Kruger, Glenn E.M. Maguire, Ian Wiid, Thavendran Govender,