| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396585 | European Journal of Medicinal Chemistry | 2009 | 7 Pages |
Abstract
A series of 3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine nucleosides (tricylic nucleosides) were synthesized from 9-[4-α-(hydroxymethyl)cyclopent-2-ene-1-α-yl]guanine (CBV) 5, (−)-β-D-(2R,4R)-1,3-dioxolane-guanosine (DXG) 6, 3′-azido-3′-deoxy-guanosine (AZG) 7, and 2′-C-methylguanosine 8. Their in vitro activity against HIV and HCV was evaluated and correlated to their ability to degrade to their purine counterpart.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Franck Amblard, Emilie Fromentin, Mervi Detorio, Alexander Obikhod, Kimberly L. Rapp, Tamara R. McBrayer, Tony Whitaker, Steven J. Coats, Raymond F. Schinazi,