Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA

Three new triorganotin(IV) dithiocarboxylates (1–3) with general formula R3SnL, where R = C4H9 (1), C6H11 (2), C6H5 (3) and L = 4-(4-nitrophenyl)piperazine-1-carbodithioate, have been synthesized and characterized by elemental analysis, Raman, FT-IR, multinuclear NMR (1H, 13C and 119Sn) and mass spectrometry. The crystal structure of complex 3 confirmed distorted trigonal-bipyramidal geometry around Sn atom. The interaction of compounds 1–3 with DNA was investigated by cyclic voltammetry (CV) and UV–vis spectroscopy. The positive peak potential shift in CV and hypochromic effect in spectroscopy evidenced intercalative mode of interaction. The results indicate that the binding affinity varies in this sequence: 1 > 3 > 2.

Graphical abstractThree new triorganotin(IV) dithiocarboxylates, have been synthesized and characterized. The interaction of compounds with DNA was investigated by cyclic voltammetry (CV) and UV–vis spectroscopy.Figure optionsDownload full-size imageDownload as PowerPoint slide