Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1396624 | European Journal of Medicinal Chemistry | 2009 | 12 Pages |
Abstract
A series of 3,3′-dindolylmethane derivatives have been synthesized and their structures were characterized in solid state by 13C CP/MAS NMR and two of them by X-ray diffraction measurements. They exhibited well expressed cytotoxicity against human melanoma cell lines. Derivatives bearing fluoro, bromo, iodo, and nitro substituents in indole or benzene rings caused 50% inhibition of the viability of ME18 and ME18/R cell lines at concentration ranging 9.7–17.3 μM.
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Related Topics
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Authors
Dorota Maciejewska, Magdalena Rasztawicka, Irena Wolska, Elżbieta Anuszewska, Beata Gruber,