Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines

Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.

Graphical abstractA series of new pyridines and pyrazolo[1,5-a]pyrimidines were prepared which showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide