Article ID Journal Published Year Pages File Type
1396736 European Journal of Medicinal Chemistry 2009 5 Pages PDF
Abstract

A facile one-pot expeditious synthesis of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described under solvent-free conditions using magnesium oxide as a catalyst in very good yields. The reaction catalyst, magnesium oxide was reused and recycled without any loss of activity and product yield. All the synthesized compounds were screened for in vitro antibacterial activity, and compounds 3a, 3b, 3f, 4b, 4c, 4d, 4e and 4g showed complete inhibition of bacterial growth at 128 μg/mL or less and the rest of the compounds exhibited incomplete inhibition.

Graphical abstractA facile one-pot expeditious synthesis and antibacterial activity of 2-amino-4H-pyrans and 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes has been described. Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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