| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396767 | European Polymer Journal | 2007 | 8 Pages |
Abstract
Regioselective quaternization of chitosan and its amphiphilic derivatives has been carried out by means of reaction with betaine in the presence of the coupling reagent 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline (EEDQ) in aqueous media at pH 5.5 ± 0.5. This reaction results in preparation of N-/(trimethylammonio)acetyl/chitosan chloride and its amphiphilic derivatives. The degree of quaternization increases with increasing EEDQ/chitosan ratio and is partly accompanied by N-ethoxycarbonylation. That side-product formation can be minimized by increasing betaine/EEDQ ratio.
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Authors
Evgeniya A. Stepnova, Vladimir E. Tikhonov, Tatiana A. Babushkina, Tamara P. Klimova, Evgeniy V. Vorontsov, Valery G. Babak, Sergey A. Lopatin, Igor A. Yamskov,