| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396814 | European Journal of Medicinal Chemistry | 2009 | 9 Pages |
Abstract
Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Katrin Groebke Zbinden, Lilli Anselm, David W. Banner, Jörg Benz, Francesca Blasco, Guillaume Décoret, Jacques Himber, Bernd Kuhn, Narendra Panday, Fabienne Ricklin, Philippe Risch, Daniel Schlatter, Martin Stahl, Stefan Thomi, Robert Unger,