| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396852 | European Journal of Medicinal Chemistry | 2009 | 7 Pages |
A series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X = H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses. The potential antibacterial effects of the synthesized compounds were investigated using the Acinetobacter baumanii ATCC 19606; Citrobacter freundii ATCC 8090; Pseudomonas aeruginosa ATCC 9027; Enterococcus faecalis ATCC 19433; Staphylococcus aureus ATCC 12600; Staphylococcus epidermidis ATCC 14990; Bacillus subtilis ATCC 6633 strains. Some of them exhibited promising activities against A. baumanii and B. subtilis.
Graphical abstractA series of Mannich bases of 4-substituted 5-[4-(4-X-phenylsulfonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thiones, X = H, Cl, Br, 3 and 5 were synthesized and characterized on the basis of IR, NMR and elemental analyses and potential antibacterial effects were investigated.Figure optionsDownload full-size imageDownload as PowerPoint slide
