| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1396916 | European Journal of Medicinal Chemistry | 2008 | 6 Pages |
Abstract
1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two conformationally restricted analogues of tocainide, were designed and synthesized as voltage-gated skeletal muscle sodium channel blockers. They showed, with respect to tocainide, a marked increase in both potency and use-dependent block.
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Authors
Alessia Catalano, Alessia Carocci, Filomena Corbo, Carlo Franchini, Marilena Muraglia, Antonio Scilimati, Michela De Bellis, Annamaria De Luca, Diana Conte Camerino, Maria Stefania Sinicropi, Vincenzo Tortorella,