Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1396970 | European Journal of Medicinal Chemistry | 2007 | 7 Pages |
Abstract
The thiosemicarbazones (3 and 6) and N-arylidene cyanoacetohydrazide (12) were prepared and used as key intermediates for the synthesis of 4-thiazolidinones (4, 5, 7–9), thiazoles (10a,b and 11a–d) and thiazoline (13) derivatives. Treatment of 13 with a mixture of triethylorthoformate and acetic anhydride afforded thiazolo[5,4-d]pyrimidinone derivative (14). The newly synthesized compounds were characterized by IR, 1H NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Samir Bondock, Wesam Khalifa, Ahmed A. Fadda,