| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397026 | European Journal of Medicinal Chemistry | 2007 | 7 Pages |
Abstract
The synthesis of a new series of 1β-methylcarbapenems having methoxyimine and substituted sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (IIIc) having methylaminosulfonamide moiety showed the most potent antibacterial activity.
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Organic Chemistry
![Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds](/preview/png/1397026.png "First Page Preview: Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds")
Authors
Heechol Jeon, Nam Hyun Jo, Kyung Ho Yoo, Joung-Hoon Choi, Heeyeong Cho, Jung-Hyuck Cho, Chang-Hyun Oh,