α-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents

In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of α-amino acids were screened for their in vitro H+/K+ ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.

Graphical abstractA series of N-acyl derivatives of α-amino acids were screened for their in vitro H+/K+-ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.Figure optionsDownload full-size imageDownload as PowerPoint slide