Synthesis of some bioactive 2-bromo-5-methoxy-N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives

Eight novel 2-bromo-5-methoxy-N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antiproliferative activity. Two of the newly synthesized compounds exhibited promising analgesic activity and one compound exhibited in vitro antiproliferative activity.

Graphical abstractEight novel 2-bromo-5-methoxy-N′-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral methods. The compounds were screened for their analgesic, antiproliferative, antifungal and antibacterial activities. Compound 3a displayed some analgesic, antiproliferative and antifungal activities.Figure optionsDownload full-size imageDownload as PowerPoint slide