| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397086 | European Journal of Medicinal Chemistry | 2007 | 5 Pages |
Abstract
Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs ≤ 4 μg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus.
Graphical abstractAntibacterial pleuromutilin derivatives containing a bicyclic nucleus are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dane M. Springer, Amy Bunker, Bing-Yu Luh, Margaret E. Sorenson, Jason T. Goodrich, Joanne J. Bronson, Kenneth DenBleyker, Thomas J. Dougherty, Joan Fung-Tomc,