Synthesis and antiproliferative activity of novel sugiol β-amino alcohol analogs

A series of β-amino alcohol analogs of sugiol were synthesized in a straightforward manner. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573 and WiDr. The most potent analogs induced considerably growth inhibition in the range 1.5–6.7 μM. The results showed that β-amino alcohol analogs are more potent than the parent compound. In addition, the derivatives with secondary amine fragments showed more active than those bearing tertiary amines.

Graphical abstractThe in vitro activity of diverse sugiol β-amino alcohol analogs against a set of human solid tumor cells is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide