Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1397141 | European Journal of Medicinal Chemistry | 2006 | 8 Pages |
Abstract
2D quantitative structure activity relationship (QSAR) model has been developed for a series of aryl heterocycle-based thrombin inhibitors. Several types of descriptors including topological, spatial, thermodynamic, information content and E-state indices were used to derive the model and genetic function approximation technique was used for variable selection.
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Authors
Sumit Deswal, Nilanjan Roy,