Antiproliferative effect of Baylis–Hillman adducts and a new phthalide derivative on human tumor cell lines

In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis–Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure–activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline–phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide