Chemotherapy of leishmaniasis part III: synthesis and bioevaluation of novel aryl substituted terpenyl pyrimidines as antileishmanial agents

Some aryl substituted terpenyl pyrimidines 4 (a–p) have been synthesized using novel synthetic methods. The compounds were screened for in vitro antileishmanial activity against promastigotes. Compounds 4c, 4i and 4l showed IC50 values as 35, 35 and 25 μg ml–1.

Graphical abstractAryl substituted terpenyl pyrimidines 4 have been synthesized using novel synthetic methods and were screened for in vitro antileishmanial activity in promastigotes.Figure optionsDownload full-size imageDownload as PowerPoint slide