| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397173 | European Journal of Medicinal Chemistry | 2006 | 6 Pages |
Abstract
The synthesis of a new series of 1β-methylcarbapenems having the substituted guanidinocarbonyl pyrrolidine moieties is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. In particular, the compound Ib having piperazinylguanidine moiety showed the most potent antibacterial activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chang-Hyun Oh, Jung-Hyuck Cho,