Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives

Some novel aminosubstituted azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine, have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. Their eventual selective effect on a phase of the cell cycle was evaluated, using HT-29 cells. A number of the new derivatives exhibited interesting cytotoxic activity against the human solid tumor cell line.

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