Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

In the course of structure–activity relationship studies, diversely substituted 1-(β-d-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide