A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

Graphical abstractIn the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated and the anti-inflammatory mechanisms were elucidated.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A concise synthesis of viscolin (1) has been achieved to construct the 1,3-diarylpropane skeleton. ► In vitro, viscolin inhibited NO, TNF-α and PGE2 productions. It also blocked iNOS, COX-2, and ERK in RAW 264.7 macrophages. ► Viscolin attenuated the MDA level in the edema paw and decreased the NO and TNF-α levels on the serum after Carr injection. ► The mechanisms related to the decrease in the level of inflammatory proteins through the suppression of TNF-α and NO.