| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397487 | European Journal of Medicinal Chemistry | 2011 | 10 Pages |
We describe a novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that β-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat.
Graphical abstractA novel class of β-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity is described in this manuscript.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► In this manuscript, we have developed a novel class of β-carboline alkaloid-peptide conjugates. ► These conjugates possess good free radical scavenging and thrombolytic activities. ► Compound 26a exerts a significant protective effect against limb I/R injury in the rat.
