| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397532 | European Journal of Medicinal Chemistry | 2011 | 4 Pages |
In this paper, we have presented the demonstration of gold nanoparticles (Au NPs) functionalized with an anticancer drug, doxorubicin. Doxorubicin was assembled on gold via amino group. The reaction proceeded under mild acidic conditions. Au NPs could not be adsorbed on doxorubicin in alkaline solution because amino group was not protonated. However, under acidic conditions, protonation created a positively charged amino group thus adsorption was easier. The interaction between Au colloids and doxorubicin is believed to be electrostatic. High-resolution TEM was used for visualization of nanoparticles, which were found to retain their average size and shape. The method, demonstrated that doxorubicin could be attached to Au NPs in a controlled manner. Our research laid the foundation of a linking methodology through which hybrid multi drug and receptor labeled NPs could be created, which might serve as an alternative design for nanosized drug-delivery systems.
Graphical abstractIn this paper, we reported a new complex of doxorubicin conjugated with gold nanoparticle. It was characterized by means of UV/visible/NIR, IR and Raman spectroscopic techniques and TEM analysis for the related metal complexes have been carried out.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► In this paper, the functionalization of Au NPs surfaces with doxorubicin is described. ► The interaction sites were investigated. ► The complexes obtained were characterized by different spectroscopic techniques.
